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SCHOOL OF MEDICINE
LABORATORY MEDICINE AND PATHOLOGY
PATHOLOGY

Detailed course offerings (Time Schedule) are available for

PATH 498 Undergraduate Thesis (*, max. 35)
Elective.

PATH 499 Undergraduate Research (*, max. 35)
Elective.

PATH 501 Pathology Proseminars (1, max. 9)
Small group discussions and presentations by students based on critical reading of original papers, or on concurrent seminars, in many areas of experimental pathology and medicine. Topic varies by quarter. Prerequisite: permission of instructor. Offered: AWSpS.

PATH 502 Inflammation and Repair (2)
Lecture-seminar; a seminar course dealing with an in-depth examination of the processes involved in inflammation and repair. Prerequisite: permission of instructor. Credit/no-credit only. Offered: even years.

PATH 507 Introduction to Pathology Research (2)
Current developments and approaches to investigation of the molecular and cellular basis of disease. Members of the Pathology faculty present and discuss their own research projects. Prerequisite: permission of instructor. Credit/no-credit only. Offered: A.

PATH 510 Introduction to Pathology Methods (3)
Laboratory course designed to introduce graduate students to the fundamentals of image analysis, histology, histopathology, post mortem evaluation, surgical pathology, and other methods used to investigate disease etiology, progression, and manifestation in humans and in animal models. Prerequisite: permission of instructor. Credit/no-credit only. Offered: A.

PATH 511 Topics in Experimental Pathology (1-2, max. 10)
Focus on areas of research relevant to experimental pathology. Prerequisite: permission of instructor. Offered: AWSpS.

PATH 512 Molecular Basis of Disease: Death and Repair (1.5)
First in a series designed to introduce students to medically important diseases and physiologic processes and experimental approaches to elucidating the cellular processes underlying these diseases. Covers basic cell/tissue processes that underlie normal homeostasis and most disease and, including apoptosis, necrosis, stem cells, inflammation, granulation tissue, tissue regeneration, repair and fibrosis.

PATH 513 Mechanisms of Neurodegeneration (1.5)
Introduction to the cellular and molecular mechanisms that underlie neurodegenerative diseases, including introduction to the normal development and anatomy of the central nervous system, a review of epidemiologic, genetic, and clinical research tools used in the investigation of these diseases, and a systematic review of the major neurodegenerative diseases.

PATH 516 Molecular Basis of Human Genetic Disease (3)
Introduces the underlying mechanisms in human genetic disorders, ranging from the single nucleotide, through genomic instability, and chromosomal rearrangements. Includes tissue and organ specific examples of the manner in which these disorders provide insights into human biology. Offered: Sp.

PATH 517 The Biology and Pathology of Aging (3/4)
Surveys the biology and pathologies of the aging phenomena in multiple species and at multiple organismal levels from whole animals to molecules. Prerequisite: coursework in biology, biochemistry, molecular biology, and genetics. Offered: Sp.

PATH 518 Emerging Topics in Cancer (2)
Science and translational advances in cancer and therapeutics, related to recent major technological progress in cancer research. Explores how knowledge of cancer genetics as well as new molecular discoveries are translated to clinical management and treatment options. Prerequisite: undergraduates by permission of instructor. ; recommended: introductory biology and/or genetics. Offered: W, odd years.

PATH 520 Experimental Pathology Seminar (1)
Review of current research in various areas of experimental pathology by members of the department and visiting scientists. Credit/no-credit only. Offered: AWSp.

PATH 521 Anatomy and Autopsy (1)
Students view an autopsy, and learn how autopsy can diagnose disease, determine cause of death, and improve patient care. Requirements include orientation session, autopsy, and a clinical-autopsy conference. Participants must be free at least one morning per week to attend an autopsy at UWMC. Prerequisite: UW medical students only. Offered: WSp.

PATH 530 Human Cytogenetics (*, max. 4)
Sources and methods of preparation and identification of human chromosomes. Molecular structure and mapping of chromosomes. Human cytogenetic pathology: karyotype-phenotype interactions, chromosome breakage, and cancer cytogenetics. Prerequisite: permission of instructor. Offered: Sp.

PATH 535 Innate Immunity and Immunopathology (1.5)
Explores the relationship between the innate immune system and disease processes, using a student-led seminar format. Students analyze, present, and critique primary research literature, and use the knowledge gained to develop a sophisticated insight into the mechanisms of immunopathology. Offered: Sp.

PATH 540 Translational Research Topics (1)
First and second year students in the M.D./Ph.D. program present and discuss current papers form the biomedical literature in journal club format, and describe their own research in seminar format. Credit/no-credit only. Offered: AWSp.

PATH 544 General and Systemic Pathology ([2-3]-, max. 5)
Basic pathologic processes that underlie disease, including cell alterations, genetic and developmental pathology, environmental pathology, neoplasia, immunopathology, inflammation, infection, and systemic diseases. Correlates gross, functional, and biochemical alterations. For first-year dental students and graduate students. Requires reasonable grounding in biological and chemical sciences. Prerequisite: for nondental students: permission of instructor.

PATH 550 Mechanisms of Disease (3)
Examines the mechanisms of inflammation, cell injury, death, repair, immunity, and neoplasia as well as diseases of various organ systems. Systems covered include the cardiovascular, pulmonary, gastrointestinal, neurologic, endocrine, and genitourinary/renal systems. Topics presented through lecture, primary literature, and small-group discussion. Offered: A.

PATH 551 Experimental and Molecular Pathology (2-5, max. 20)
Introduction to experimental pathology. A tutorial course designed to introduce a graduate student (medical, dental) or senior undergraduate to selected methods and problems through literature surveys and/or laboratory experience. Exploration of causes at the cellular and molecular levels in the study of disease is emphasized. Prerequisite: Pathology PhD student; permission of instructor Credit/no-credit only. Offered: AWSp.

PATH 555 Environmental Pathology (3)
Modern morphologic, cell biological, and molecular approaches to environmental disease associated with exposure/predisposition. Lectures, seminar discussion, and student presentations. Prerequisite: PATH 410 or PATH 444 or HUBIO 520. Offered: Sp, even years.

PATH 558 Integrative Omics (1.5)
Explores how to integrate genomic, transcriptomic, and proteomic approaches with state-of-the-art genetic engineering strategies to uncover a systems-level understanding of pathway interactions that regulate disease pathogenesis and complex phenotypes. Recommended: undergraduate biology or cellular and molecular biology. Offered: jointly with MOLMED 558; Sp.

PATH 560 Molecular Analysis of Human Disease (*, max. 10)
Review and discussion of contemporary research on molecular basis of human disease. Focus on mutational mechanisms, genetic instability, AIDS, and cancer. Students participate in weekly group discussion and work with faculty to select, develop, and present discussion topic. Prerequisite: medical, graduate, or professional standing and permission of instructor. Credit/no-credit only. Offered: AWSp.

PATH 580 Mitochondria and Metabolism in the Pathogenesis of Human Disease (1.5)
Explores the fundamentals of mitochondrial biology, bioenergetics, and cellular metabolism. Includes topical lectures and literature reviews introducing students to advanced metabolic concepts within the context of human disease. Offered: W, even years.

PATH 590 Patient-Centered Translational Research (1)
MSTP students preparing to return to clerkships are partnered with a senior MD/PhD medical student or house office, preview the medical or surgical ward team environment, select a patient-focused translation research topic based on their clinical experience, and prepare a plan for refreshing introductory clinical skills. Offered: WSp.

PATH 600 Independent Study or Research (*-)
Prerequisite: Pathology PhD student. Credit/no-credit only. Offered: AWSpS.

PATH 667 P-Renal Pathology Laboratory (*, max. 6)
Laboratory elective for third- and fourth-year medical students. Read current literature, review various renal biopsies and urine sediments, and read standard texts prior to a weekly topic-oriented conference. All students earn 1 credit for one-hour seminar per week. May be taken concurrently with MED 693. Prerequisite: permission of instructor.

PATH 675 P-Diagnostic Pathology Clerkship - Missoula (4, max. 24)
Medical student participation in microscopic examination, laboratory specimen processing and on occasion aid surgeons, endoscopists or radiologists with immediate evaluation of specimens.

PATH 676 P-Diagnostic Pathology Clerkship - Spokane (*, max. 24)
Medical student participation in dissection and study of autopsy and surgical pathology cases at Sacred Heart Medical Center in Spokane. Can be taken for either two or four weeks.

PATH 677 P-Neuropathology Clerkship - HMC (*, max. 16)
Includes participation in dissection and study of neuropathology cases. Students work up cases under senior staff including dissection, microscopic examination, and literature review.

PATH 678 P-Diagnostic Pathology Clerkship - Medical Examiner's Office, Alaska (*, max. 24)
Medical student participation in dissection and study of autopsy and forensic pathology cases at the Anchorage Medical Examiner's Office.

PATH 680 P-Diagnostic Pathology Clerkship - °Ä²ÊÍø Medical Center (*, max. 24)
Medical student participation in dissection and study of autopsy and surgical pathology cases. Cases worked up under senior staff, including dissection, microscopic examination, and literature review. Attendance at pathology conferences and seminars expected. Prerequisite: third- or fourth-year medical student standing.

PATH 681 P-Diagnostic Pathology Clerkship - Harborview Medical Center (*, max. 24)

PATH 682 P-Diagnostic Pathology Clerkship - Veterans' Administration Hospital (*, max. 24)

PATH 683 P-Forensic Pathology Clerkship - Medical Examiner's Office (*, max. 24)

PATH 686 P-Diagnostic Pathology Clerkship (4/8)
Provides medical students an opportunity to improve on gross and microscopic diagnosis, and to experience what it is like to be a pathology resident at the °Ä²ÊÍø. Participants pair with a trainee and faculty mentors to serve as a source of information and guidance. Students attend resident didactics, tumor boards, daily signouts, discussion groups, and personalized slide sessions Prerequisite: completion of the UW School of Medicine foundations and patient care phases. Offered: AWSpS.

PATH 688 P-Diagnostic Pathology Clerkship - Madigan Army Medical Center (*, max. 24)

PATH 697 P-Pathology Special Electives (*, max. 24)
By specific arrangement, students have clerkships, externships, or research opportunities at institutions other than the °Ä²ÊÍø. Prospective students obtain special assignment forms from the dean's office at least one month before advance registration. Prerequisite: permission of instructor.

PATH 699 P-WWAMI Pathology Special Electives (*, max. 24)
By special arrangement for qualified students, special clerkships or externships may be available at institutions, other than the °Ä²ÊÍø, located within the WWAMI region. Prerequisite: permission of department.

PATH 700 Master's Thesis (*-)

PATH 800 Doctoral Dissertation (*-)
Prerequisite: Pathology PhD student. Offered: AWSpS.